You are here

Delays in shipping: Due to current delays in our warehouse shipping services, please expect longer than usual delivery times for any print journal orders. Our books are available as usual via retailers and online from Amazon.com.au.

Digital inspection copies are still available to request. If you require a print inspection copy, please contact your local Academic Sales Consultant.

For further assistance please visit our Contact us page. Thank you for your patience and we apologise for the inconvenience.

ICRP Publication 83
Share
Share

ICRP Publication 83
Risk Estimation for Multifactorial Diseases


Other Titles in:
Public Health | Radiology

December 2000 | 136 pages | SAGE Publications Ltd
ICRP Publication 83 reviews data on naturally occurring multifactorial diseases and develops a mathematical model to predict the impact of radiation induced mutations on the frequencies of these diseases in the population. It provides a broad outline of the aetiological features and examples of multifactorial diseases. It considers the concepts and models used to explain their inheritance patterns, with particular emphasis on the Multifactorial Threshold Model. Conceptual differences from ‘mendelian’ diseases are discussed, and pertinent epidemiology is reviewed. Particular attention is paid to diabetes mellitus and to coronary heart disease. Mechanistic models in population genetics are considered. The concepts of liability, threshold, mutation-selection balance, and mutation component are integrated into a Finite Locus Threshold Model as a basis for risk estimation. The relevance of these findings for estimation of radiation risk of multifactorial diseases is discussed.

For instructors

This book is not available as an inspection copy. For more information contact your local sales representative.

Purchasing options

Please select a format:

ISBN: 9780080439006
£187.00